In 2012, fans bid farewell to the iconic doctors of Princeton-Plainsboro Teaching Hospital in House M.D.. More than 20 years since its 2004 premiere, what paths have the stars taken? As longtime enthusiasts of the series, we've tracked their impressive careers.
From 2004 to 2012 on Fox (and TF1 internationally), House M.D. captivated audiences with its mind-bending medical mysteries, solved by the brilliant yet abrasive Dr. Gregory House and his diagnostic team. Some episodes even inspired real-life physicians to save patients. Over eight seasons, viewers grew attached to the cane-wielding cynic, whose Vicodin-fueled risks pushed ethical boundaries to rescue lives. Nearly 12 years post-finale, here's where the main cast stands today.

The British star who brought the grumpy genius to life stepped back after the series but returned to his film roots (think 101 Dalmatians and Stuart Little). He shone alongside George Clooney in Tomorrowland and recently in The Personal History of David Copperfield. On TV, Laurie marked his 60th birthday in 2019 while portraying a neuropsychiatrist in Chance, a politician in Veep, and an arms dealer in The Night Manager.

After leaving as hospital dean in season 8, Edelstein guested on The Good Wife and Scandal. She led Girlfriends' Guide to Divorce (2014-2018) as a self-help author navigating separation. Post-finale, she joined Netflix's The Kominsky Method and recurred on The Good Doctor.

House's loyal friend and oncologist, previously standout in Dead Poets Society with Robin Williams, faced a career lull but rebounded with guest spots on The Blacklist, The Good Wife, and The Good Doctor. He held recurring roles in SVU and Spielberg's Falling Skies.

Post-House, Epps starred in supernatural drama Resurrection (canceled after two seasons), led as a Secret Service agent in Shooter, and guested on This Is Us season 4. On film, he tackled intense roles in Trick and Fatal Affair.

Exiting in season 6, Morrison dove into fantasy as Emma Swan in Once Upon a Time from 2011 and guested on This Is Us season 4. She's since pivoted to directing, helming Netflix's Sun Dogs and episode 5 of Euphoria starring Zendaya.

The Australian anesthesiologist traded scrubs for firefighter gear in Chicago Fire, leading as Matthew Casey for over a decade. He crosses over into spin-offs Chicago Med and Chicago P.D., perfectly suiting his life-saving persona.

Introduced in season 4 as the plastic surgeon, Jacobson recurred on Ray Donovan, guested in Colony and The Americans, and since 2019 plays a rabbi in Fear the Walking Dead.

House's enigmatic "Thirteen" thrived post-series, starring in HBO's Vinyl before focusing on film and directing. Her debut Booksmart hit Netflix, followed by helming the thriller Don't Worry Darling.
Stream House M.D. on Prime Video. Explore fates of Grey's Anatomy departures or Netflix's top detective series from 2020.